Effects of anthocyanins on the prevention and treatment of cancer.
Br J Pharmacol. 2016 Sep 20. Epub 2016 Sep 20. PMID: 27646173
Anthocyanins are a class of water-soluble flavonoids, which show some pharmacological effects, such as prevention of cardiovascular disease, obesity control and anti-tumour activity. Their potential anti-tumour effects are reported to be based mainly on antioxidant, anti-inflammation, anti-mutagenesis, induction of differentiation, inhibiting proliferation by modulating signal transduction pathways, inducing cell cycle arrest and stimulating apoptosis or autophagy of cancer cells; anti-invasion and anti-metastasis; reversing drug resistance of cancer cells; and increasing their sensitivity to chemotherapy. In this review, the latest progress on the anti-cancer activities of anthocyanins and the underlying molecular mechanisms are summarized using data from basic research in vitro and in vivo, from clinic trails and taking into account theory and practice. This article is protected by copyright. All rights reserved.