A review of the possible use of Punica granatum in cancer therapy. - GreenMedInfo Summary
Possible use of Punica granatum (Pomegranate) in cancer therapy.
Pharmacol Res. 2018 May 2. Epub 2018 May 2. PMID: 29729421
Amrita Devi Khwairakpam
The intake of fruits has proven to reduce the risk and incidence of cancer worldwide and plays a crucial role in cancer prevention. Pomegranate (Punica granatum), which belongs to the Punicaceae family, is one such plant that contains beneficial nutrients as well as many bioactive components and important phytochemicals that can be attributed to cancer-related therapeutic purposes. Pomegranate possesses antioxidant, anti-inflammatory, anti-proliferative, anti-angiogenic, anti-invasive, and anti-metastatic properties, and induces apoptosis. It also down-regulates various signalling pathways such as NF-κB, PI3K/AKT/mTOR, and Wnt, and down-regulates the expression of genes that are responsible in cancer development, such as anti-apoptotic genes, MMPs, VEGF, c-met, cyclins, Cdks, and pro-inflammatory cytokines. Therefore, inclusion of the fruit in one's diet would assist in a healthy life protectedfrom cancer and also act as an effective chemotherapeutic with no toxic side effects.