Garlic and its Active Compounds: A Potential Candidate in The Prevention of Cancer by Modulating Various Cell Signalling Pathways.
Anticancer Agents Med Chem. 2019 Apr 8. Epub 2019 Apr 8. PMID: 30963982
Saleh A Almatroodi
BACKGROUND: Cancer is a multi-factorial disease including alterations in the cell signalling pathways. Currently, several drugs are in use to treat the cancer but such drugs show negative side effects on normal cells and causes severe toxicity.
METHODS: The current research is mainly focused on medicinal plants with potential therapeutic efficacy in the treatment of cancer without any adverse effects on normal cells. In this regards, garlic and its active compounds including diallyl sulphide, diallyl trisulfide, ajoene and allicin has been established to suppress the growth of cancer and killing of cancer cells.
RESULT: The review concerns about garlic and its active compounds chemopreventive effect through modulating various cell signalling pathways. Additionally, Garlic and its active compound was established to induce cell cycle arrest at the G0/G1 phase and G2/M phases in cancer cells, increased the expression of tumor suppressor genes, inhibition of angiogenesis process, induction of apoptosis and modulating various other genetic pathways.
CONCLUSION: This review sketches the diverse chemopreventive activities of garlic and their active ingredients in the management of cancer mainly focusing on cell signalling pathways.