Abstract Title:

Therapeutic potency of crocin in the treatment of inflammatory diseases: Current status and perspective.

Abstract Source:

J Cell Physiol. 2019 Jan 23. Epub 2019 Jan 23. PMID: 30673132

Abstract Author(s):

Mehran Pashirzad, Mojtaba Shafiee, Amir Avan, Mikhail Ryzhikov, Hamid Fiuji, Amirhossein Bahreyni, Majid Khazaei, Saman Soleimanpour, Seyed Mahdi Hassanian

Article Affiliation:

Mehran Pashirzad


Crocin is the major component of saffron, which is used in phytomedicine for the treatment of several diseases including diabetes, fatty liver, depression, menstruation disorders, and, of special interest in this review, inflammatory diseases. Promising selective anti-inflammatory properties of this pharmacological active component have been observed in several studies. Saffron has been shown to exert anti-inflammatory properties against several inflammatory diseases and can be used as a novel therapeutic agent for the treatment of inflammatory diseases either alone or in combination with other standard anti-inflammatory agents. This review summarizes the protective role of saffron and its pharmacologically active constituents in the pathogenesis of inflammatory diseases including digestive diseases, dermatitis, asthma, atherosclerosis, and neurodegenerative diseases for a better understanding and hence a better management of these diseases.

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