Rhabdomyolysis and acute renal failure due to statin-fibrate combinations has been reported. - GreenMedInfo Summary
Rhabdomyolysis and acute renal failure after changing statin-fibrate combinations.
Cardiology. 2000 ;94(2):127-8. PMID: 11173785
Department of Internal Medicine, Creighton University, Omaha, NE, USA.
Statin-fibrate combinations are commonly used to treat hyperlipidemia. These drugs have been previously reported to cause rhabdomyolysis with acute renal failure. Whether different statin-fibrate combinations have different risks for rhabdomyolysis is not known. We report a patient who developed rhabdomyolysis with acute renal failure promptly after switching from the combination of pravastatin and fenofibrate to simvastatin and gemfibrozil.