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Abstract Title:

Rheumatic Fever: A Model of Autoimmune Disease due to Molecular Mimicry between Human and Pathogen Proteins.

Abstract Source:

Crit Rev Immunol. 2020 ;40(5):419-422. PMID: 33463953

Abstract Author(s):

Jorge Kalil, Luiza Guilherme

Article Affiliation:

Jorge Kalil

Abstract:

Acute rheumatic fever (ARF) is caused by an autoimmune response to throat infection with Streptococcus pyogenes in individuals who present some susceptibility genes. Rheumatic heart disease (RHD) is the major sequela and can cause heart failure and premature mortality. The disease is mediated by humoral and cellular immune responses. In this review, we present the major events that can trigger heart lesions.

Study Type : Review

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Sayer Ji
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