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Abstract Title:

Rhubarb inhibits hepatocellular carcinoma cell metastasis via GSK-3-β activation to enhance protein degradation and attenuate nuclear translocation of β-catenin.

Abstract Source:

Food Chem. 2013 May 1 ;138(1):278-85. Epub 2012 Nov 8. PMID: 23265488

Abstract Author(s):

Kun-Hsi Tsai, Hau-Hsueh Hsien, Li-Mien Chen, Wei-Jen Ting, Yuh-Shyong Yang, Chia-Hua Kuo, Chang-Hai Tsai, Fuu-Jen Tsai, Henry J Tsai, Chih-Yang Huang

Article Affiliation:

Kun-Hsi Tsai

Abstract:

The aim of our study was to investigate the mechanisms by which rhubarb regulatesβ-catenin as well as metastasis of hepatocellular carcinomas. Our results revealed that rhubarb extract inhibited HA22T cell migration ability in wound healing, migration and invasion assays in a dose-dependent manner. Rhubarb also reduced β-catenin protein level, downregulated its downstream proteins, cyclin D, Tbx3 and c-Myc, and attenuated the expression of MMP9 and contactin-1 metastatic factors. Additionally, rhubarb inhibited β-catenin nuclear accumulation and induced its degradation via proteasome-mediated pathway. Furthermore, we found that rhubarb suppressed the p-ser(9) GSK-3-β protein level to inactivate Wnt signalling and reduce β-catenin protein level. Taken together; we found that rhubarb blocked the metastatic process of HA22T hepatocellular carcinoma cells mediated through GSK-3-β activation, and enhancement of protein degradation as well as reduction of the nuclearaccumulation of β-catenin.

Study Type : In Vitro Study

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Sayer Ji
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