n/a
Article Publish Status: FREE
Abstract Title:

Dietary riboflavin deficiency promotes N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in rats by inducing chronic inflammation.

Abstract Source:

Am J Cancer Res. 2019 ;9(11):2469-2481. Epub 2019 Nov 1. PMID: 31815047

Abstract Author(s):

Feng Pan, Ye Chen, Jian-Zhong He, Lin Long, Yang Chen, Hong-Jun Luo, Yi-Wei Xu, Xiao-Xiao Pang, Qian Yang, Juan-Juan Wang, Xiu-E Xu, Shao-Hong Wang, En-Min Li, Li-Yan Xu

Article Affiliation:

Feng Pan

Abstract:

Epidemiological studies in high-incidence areas of esophageal cancer in China suggest that environmental carcinogen N-nitrosomethylbenzylamine (NMBA) and riboflavin (RBF) deficiency may be the main risk factors for esophageal cancer. However, it is not clear that the combination induces cancer. Here, experiment (Exp) 1 evaluated the effects of NMBA and RBF deficiency individually or in combination on esophageal tumorigenesis. Male F344 rats were randomly assigned to 4 groups into a 2 (no NMBANMBA)× 2 (normal RBFRBF-deficient) factorial design, including normal RBF (6 mg/kg, R), RBF-deficient (0 mg/kg, R), normal RBF combined with NMBA (RN), and RBF-deficient combined with NMBA (RN) groups. The Exp 2 explored the effects of RBF deficiency at different doses combined with NMBA (0.6 mg/kg, RN; 0.06 mg/kg, RN) on esophageal tumorigenesis. Results showed that RN enhanced the incidence of esophageal intraepithelial neoplasia (EIN, 53.3%,= 0.06), including carcinoma, whereas RN mainly induced the occurrence of esophageal benign hyperplasia (38.9%) and EIN (16.7%). RBF deficiency promotes EIN in a dose-dependent manner, and RN significantly increases the incidence of EIN (57.9%,<0.05). Gene expression profiling demonstrated that inflammatory cytokines were highly expressed in RN EIN tissues, whereas RN EIN tissues had a proliferation and differentiation gene signature (fold-change>1.5). Furthermore, RBF deficiency aggravated oxidative DNA damage (8-OHdG) and double-strand breaks (γH2AX) (<0.05). Our results suggest that RBF deficiency causes chronic inflammation-associated genomic instability contributes to NMBA-induced esophageal tumorigenesis.

Study Type : In Vitro Study

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.