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Article Publish Status: FREE
Abstract Title:

Rice bran modulates renal disease risk factors in animals submitted to high sugar-fat diet.

Abstract Source:

J Bras Nefrol. 2021 Jan 15. Epub 2021 Jan 15. PMID: 33475676

Abstract Author(s):

Juliana Silva Siqueira, Fabiane Valentini Francisqueti-Ferron, Jéssica Leite Garcia, Carol Cristina Vágula de Almeida Silva, Mariane Róvero Costa, Erika Tiemi Nakandakare-Maia, Fernando Moreto, Ana Lúcia A Ferreira, Igor Otávio Minatel, Artur Junio Togneri Ferron, Camila Renata Corrêa

Article Affiliation:

Juliana Silva Siqueira

Abstract:

INTRODUCTION: Obesity, diabetes, and hypertension are common risk factors for chronic kidney disease (CKD). CKD arises due to many pathological insults, including inflammation and oxidative stress, which affect renal function and destroy nephrons. Rice bran (RB) is rich in vitamins and minerals, and contains significant amount of antioxidants. The aim of this study was to evaluate the preventive effect of RB on renal disease risk factors.

METHODS: Male Wistar rats (±325 g) were divided into two experimental groups to received a high sugar-fat diet (HSF, n = 8) or high sugar-fat diet with rice bran (HSF + RB, n = 8) for 20 weeks. At the end, renal function, body composition, metabolic parameters, renal inflammatory and oxidative stress markers were analyzed.

RESULTS: RB prevented obesity [AI (HSF= 9.92± 1.19 vs HSF + RB= 6.62 ± 0.78)ENT#093;, insulin resistance [HOMA (HSF= 83 ± 8 vs. HSF + RB= 42 ± 11)ENT#093;, dyslipidemia [TG (HSF= 167 ± 41 vs. HSF + RB=92 ± 40)ENT#093;, inflammation [TNF-α (HSF= 80 ± 12 vs. HSF + RB=57 ± 14), IL-6 (903 ± 274 vs. HSF + RB=535 ± 277)], oxidative stress [protein carbonylation (HSF= 3.38 ± 0.18 vs. HSF + RB=2.68 ± 0.29), RAGE (HSF=702 ± 36 vs. RSF + RB=570 ± 190)], and renal disease [protein/creatinine ratio (HSF=1.10 ± 0.38 vs. HSF + RB=0.49 ± 0.16)].

CONCLUSION: In conclusion, rice bran prevented renal disease by modulating risk factors.

Study Type : Animal Study

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