Article Publish Status: FREE
Abstract Title:

Rind from Purple Mangosteen () Attenuates Diet-Induced Physiological and Metabolic Changes in Obese Rats.

Abstract Source:

Nutrients. 2021 Jan 22 ;13(2). Epub 2021 Jan 22. PMID: 33499382

Abstract Author(s):

Oliver D John, Peter Mouatt, Sunil K Panchal, Lindsay Brown

Article Affiliation:

Oliver D John


The pulp of the purple mangosteen,, is a popular tropical fruit but the rind containing xanthones such asα-mangostin together with procyanidins and anthocyanidins is usually discarded as waste. However, this rind has been used in South-East Asia for diarrhoea, dysentery, skin infections and wounds. As xanthones have reported anti-inflammatory and antioxidant responses, this study has determined the bioactive compounds and evaluated the effects ofrind on physiological, metabolic, liver and cardiovascular parameters in rats with diet-induced metabolic syndrome. Rats fed a diet with increased simple sugars and saturated fats developed obesity, hypertension, increased left ventricular stiffness, dyslipidaemia and fatty liver. Administration ofrind as 5% of the food to rats with diet-induced metabolic syndrome gave a dose of 168 mg/kg/dayα-mangostin, 355 mg/kg/day procyanidins, 3.9 mg/kg/day anthocyanins and 11.8 mg/kg/day hydroxycitric acid for 8 weeks which reduced body weight and attenuated physiological and metabolic changes in rats including decreased abdominal fat deposition, decreased abdominal circumference and whole-body fat mass, improved liver structure and function and improved cardiovascular parameters such as systolic blood pressure, left ventricular stiffness and endothelial function. These responses were associated with decreased infiltration of inflammatory cells, decreased deposition of collagen in both heart and liver and decreased mean adipocyte size in retroperitoneal adipose tissues. We conclude that, in rats with diet-induced metabolic syndrome, chronic intake ofrind decreased infiltration of inflammatory cells which decreased physiological, metabolic, liver and cardiovascular symptoms.

Study Type : Animal Study

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