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Article Publish Status: FREE
Abstract Title:

The Role of Dietary Antioxidants on Oxidative Stress in Diabetic Nephropathy.

Abstract Source:

Iran J Kidney Dis. 2020 Mar ;14(2):81-94. PMID: 32165592

Abstract Author(s):

Francisco Gerardo Yanowsky-Escatell, Jorge Andrade-Sierra, Leonardo Pazarín-Villaseñor, Christian Santana-Arciniega, Eduardo De Jesús Torres-Vázquez, Jonathan Samuel Chávez-Iñiguez, Miguel Ángel Zambrano-Velarde, Francisco Martín Preciado-Figueroa

Article Affiliation:

Francisco Gerardo Yanowsky-Escatell

Abstract:

Diabetic nephropathy (ND) is the leading cause of end-stage renal disease and oxidative stress (OS) has been recognized as a key factor in the pathogenesis and progression. Hyperglycemia, reactive oxygen species, advanced glycation end products, arterial pressure, insulin resistance, decrease in nitric oxide, inflammatory markers, and cytokines, among others; are involved in the presence of OS on ND. This revision focus on diverse studies in experimental and human models with diabetes and DN that has been demonstrated beneficial effects of different dietary antioxidant as resveratrol, curcumin, selenium, soy, catechins,α-lipoic acid, coenzyme Q10, omega-3 fatty acids, zinc, vitamins E and C, on OS and the capacity for antioxidant response. Therefore, this interventions could have a positive clinical impact on DN.

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