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Article Publish Status: FREE
Abstract Title:

The role of299v in supporting treatment of selected diseases.

Abstract Source:

Cent Eur J Immunol. 2020 ;45(4):488-493. Epub 2021 Jan 25. PMID: 33613097

Abstract Author(s):

Karolina Kaźmierczak-Siedlecka, Agnieszka Daca, Marcin Folwarski, Jacek M Witkowski, Ewa Bryl, Wojciech Makarewicz

Article Affiliation:

Karolina Kaźmierczak-Siedlecka

Abstract:

Alterations in composition of human gut microbiome can lead to its dysbiosis. It is associated with gastrointestinal side effects during anti-cancer treatment, antibiotics administration, or infectious agents. There are studies confirming positive effect of consuming Lactobacillus plantarum 299v on intestinal microflora. This review summarizes the current knowledge about the role of L. plantarum 299v in supporting treatment of selected diseases, such as cancer, irritable bowel syndrome (IBS), and Clostridium difficile infection. The immunomodulating properties of L. plantarum 299v include an increase in the level of anti-inflammatory cytokines, which reduce the risk of cancer and improve the efficacy of regimens. The intake of L. plantarum 299v provides benefits for IBS patients, mainly due to normalization of stool and relief of abdominal pain, which significantly improves the quality of life of IBS patients. In addition, the intake of L. plantarum 299v prevents C. difficile-associated diarrhea among patients receiving antibiotic treatment. Due to the limited possibilities of treating these diseases and numerous complications of cancer treatment, there is a need for new therapeutic strategies. The administration of L. plantarum 299v seems to be useful in these cases.

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