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Abstract Title:

Quercetin and non-alcoholic fatty liver disease: a review based on experimental data and bioinformatic analysis.

Abstract Source:

Food Chem Toxicol. 2021 Jun 1:112314. Epub 2021 Jun 1. PMID: 34087406

Abstract Author(s):

Li Chen, Jingjing Liu, Guibin Mei, Huimin Chen, Shufen Peng, Ying Zhao, Ping Yao, Yuhan Tang

Article Affiliation:

Li Chen

Abstract:

Quercetin, a polyphenol widely present in the plant kingdom, has received great interest due to pleiotropic effects. As evidenced by animal and cellular studies, quercetin exerts hepatoprotection against non-alcoholic fatty liver disease (NAFLD), particularly in hepatic steatosis and hepatitis. Mechanically, various hypotheses of such protective effects have been actively proposed, including improving fatty acid metabolism, anti-inflammation, anti-oxidant, modulating gut microbiota and bile acid, etc. Here, the role of quercetin in NAFLD was summarized. With a particular focus on molecular mechanism, we comprehensively discussed the pathways of quercetin on NAFLD based on the analysis from Gene Expression Omnibus (GEO) database and experimental evidence.

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