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Abstract Title:

The anti-HIV activity and mechanisms of action of pure compounds isolated from Rosa damascena.

Abstract Source:

Biochem Biophys Res Commun. 1996 Dec 4;229(1):73-9. PMID: 8954085

Abstract Author(s):

N Mahmood, S Piacente, C Pizza, A Burke, A I Khan, A J Hay

Article Affiliation:

MRC Collaborative Centre, London, United Kingdom.

Abstract:

Water and methanol extracts of Rosa damascena exhibited moderate anti-HIV activity. The anti-viral activities of 9 compounds isolated from the methanol extract were compared. The tetrahydroxyflavanone (kaempferol, 1), was effective in reducing the maturation of infectious progeny virus apparently due to selective inhibition of the viral protease. On the other hand the pentahydroxyflavone (quercetin, 2) and two 3-substituted derivatives of kaempferol appeared to inhibit HIV-infection by preventing binding of gp120 to CD4. 2-Phenylethanol-O-(6-O-galloyl)-beta-D-glucopyranoside 8 interacted irreversibly with gp120 and neutralized virus infectivity. The differences in the modes of action of 1 and 8 can account for the apparent synergy of their anti-viral activities.

Study Type : In Vitro Study

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Sayer Ji
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