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Abstract Title:

COX-1 and -2 activity of rose hip.

Abstract Source:

Phytother Res. 2007 Dec;21(12):1251-2. PMID: 17639563

Abstract Author(s):

A K Jäger, I M S Eldeen, J van Staden

Abstract:

The objective of this study was to investigate whether the clinically observed efficacy of rose hip in the treatment of osteoarthritis is due to inhibition of cyclooxygenase-1 and -2. Water, methanol, dichloromethane and hexane extracts of rose hip were tested for in vitro COX-1 and 2 activity. The organic solvent extracts showed good inhibition of both COX-1 and 2. The methanol extract was most active in both assays with IC(50) values of 12 microg/mL for COX-1 and 19 microg/mL for COX-2. The clinically observed effect might be due to inhibition of cyclooxygenase. Copyright (c) 2007 John Wiley & Sons, Ltd.

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Sayer Ji
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