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Abstract Title:

Rosmarinic Acid: A Naturally Occurring Plant Based Agent Prevents Impaired Mitochondrial Dynamics and Apoptosis in Ultraviolet-B -Irradiated Human Skin Cells.

Abstract Source:

Photochem Photobiol. 2021 Oct 4. Epub 2021 Oct 4. PMID: 34608633

Abstract Author(s):

Divya Gupta, Archoo Sajida, Naikoo Hussain Shahid, Sheikh Abdullah Tasduq

Article Affiliation:

Divya Gupta

Abstract:

Ultraviolet B (UVB) radiation is the leading cause of premature skin aging and skin cancer. UVB mediated mitochondrial dysfunction has been identified as one of the causative factors of UVB induced oxidative imbalance and apoptosis. Here we report that UVB leads to mitochondrial fragmentation by causing imbalance in the markers regulating mitochondrial dynamics, which further contributes to ROS imbalance and activation of mitochondrial apoptotic signals. Several studies have demonstrated natural products as inhibitors of mitochondrial fission. However, to our knowledge, not much evidence has been gathered regarding utilization of Rosmarinic acid against UVB orchestrated mitochondrial fragmentation responses. Thus, in our study, we present the evidence of the efficacy of Rosmarinic Acid as a modulator of mitochondrial dynamics in UVB irradiated skin cells to prevent oxidative imbalance and apoptosis, thereby, preventing UVB induced photodamage.

Study Type : In Vitro Study

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