Abstract Title:

Rosmarinic acid, a photo-protective agent against UV and other ionizing radiations.

Abstract Source:

Food Chem Toxicol. 2009 Feb;47(2):386-92. Epub 2008 Nov 30. PMID: 19084569

Abstract Author(s):

M Sánchez-Campillo, J A Gabaldon, J Castillo, O Benavente-García, M J Del Baño, M Alcaraz, V Vicente, N Alvarez, J A Lozano

Article Affiliation:

Food Safety Department, Centro Tecnológico Nacional de Conserva y Alimentación, Concordia s/n, 20500 Molina de Segura, Murcia, Spain.

Abstract:

Solar UV and other ionizing radiations cause a generation of reactive oxygen species, induce cellular DNA damage and alter skin homeostasis. The use of exogenous antioxidants is increasingly frequents, we attempt to demonstrate that a rosmarinic acid extract acts as photo-protector; both free radical scavenger as an inducer of the body's own endogenous defence mechanisms by regulating tyrosinase activity and stimulating melanin production. Malonyldialdehyde formation (TBARS) was delayed when RA was used. The protection factor was 3.24 times vs AA. TEAC value for RA was 1.6 times vs AA. The radioprotective-antimutagenic effects of RA were measure using the micronucleus test. The level of micronucleous for treatments before irradiation was: RA [14]

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