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Abstract Title:

Rosmarinic acid inhibits poly(I:C)-induced inflammatory reaction of epidermal keratinocytes.

Abstract Source:

Life Sci. 2016 Jun 15 ;155:189-94. Epub 2016 May 17. PMID: 27210890

Abstract Author(s):

Ming-Wei Zhou, Ri-Hua Jiang, Ki-Duck Kim, Jin-Hyup Lee, Chang-Deok Kim, Wei-Tian Yin, Jeung-Hoon Lee

Article Affiliation:

Ming-Wei Zhou

Abstract:

AIMS: Keratinocytes are the predominant cells in the epidermis, exerting their primary role of physical barrier through sophisticated differentiation process. In addition, keratinocytes contribute to the activation of innate immunity, providing the surveillant role against external pathogens. It has been known that chronic skin inflammatory disease such as psoriasis can be provoked by viral pathogens including double-stranded RNA. In this study, we demonstrated that rosmarinic acid (RA) has an inhibitory potential on inflammatory reaction induced by double-stranded RNA mimic poly(I:C) in epidermal keratinocytes.

MAIN METHODS: We cultured human epidermal keratinocytes and induced inflammatory reaction by poly(I:C) treatment. The effect of RA on inflammatory reaction of keratinocytes was determined by RT-PCR and Western blot.

KEY FINDINGS: RA significantly inhibited poly(I:C)-induced expression of inflammatory cytokines including IL-1β, IL-6, IL-8, CCL20, and TNF-α, and downregulated NF-κB signaling pathway in human keratinocytes. In addition, RA significantly inhibited poly(I:C)-induced inflammasome activation, in terms of secretion of active form of IL-1β and caspase-1. Furthermore, RA markedly inhibited poly(I:C)-inducedNLRP3 and ASC expression.

SIGNIFICANCE: These results indicate that RA can inhibit poly(I:C)-induced inflammatory reaction of keratinocytes, and suggest that it may be a potential candidate for the treatment of psoriasis.

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