Glyphosate-surfactant herbicide-induced reversible encephalopathy.
J Clin Neurosci. 2010 Jul 22. Epub 2010 Jul 22. PMID: 20655231
Department of Neurology, Liverpool Health Service, Level 1 CSB Locked Bag 7103, Liverpool BC, New South Wales 1871, Australia; South Western Sydney Clinical School, Faculty of Medicine, The University of New South Wales, Sydney 2052, Australia.
Glyphosate-surfactant (GlySH) is a commonly used herbicide that has been used in attempted suicide. Most reports of GlySH toxicity in patients have followed ingestion of the commercial product "Round-up" (Monsanto Ltd; Melbourne, Victoria, Australia), which consists of a mixture of glyphosate (as a isopropylanine salt) and a surfactant (polyoxyethyleneamine). Ingestion of Round-up is reported to cause significant toxicity including nausea, vomiting, oral and abdominal pain. Renal and hepatic impairment and pulmonary oedema may also occur. Impaired consciousness and encephalopathy have been reported as sequelae but there are limited data on the central nervous system (CNS) effects of Round-up toxicity. We report a 71-year-old male who attempted suicide with GlySH and developed a prolonged but reversible encephalopathy suggestive of acute CNS toxicity.