n/a
Abstract Title:

Royal jelly abrogates flouride-induced oxidative damage in rat heart tissue by activating of the Nrf-2/NF-κB and Bcl-2/Bax pathway.

Abstract Source:

Toxicol Mech Methods. 2021 Jul 6:1-29. Epub 2021 Jul 6. PMID: 34227456

Abstract Author(s):

Abdullah Aslan, Seda Beyaz, Ozlem Gok, Muhammed Ismail Can, Gozde Parlak, Ibrahim Hanifi Ozercan, Ramazan Gundogdu

Article Affiliation:

Abdullah Aslan

Abstract:

Royal jelly is known to strengthen memory, provide antioxidative, antidiabetic, antitumor, anticancer, antibacterial, anti-inflammatory, antihypertensive. In this study, 42 rats (n = 42) were used, and these rats were divided into 6 groups of 7 rats each. Groups: (i) Control Group: Group fed with standard diet; (ii) Royal Jelly (RJ) Group: RJ (100 mg/kg CA, gavage); (iii) F50 Group: Fluoride (50 mg/kg CA, drinking water); (iv) F100 Group: F (100 mg/kg CA, drinking water); (v) F50 + RJ Group: F (50 mg/kg CA, drinking water) + RJ (100 mg/kg CA, gavage); (vi) F100 + RJ Group: F (100 mg/kg CA, drinking water) + RJ (100 mg/kg CA, gavage). The rats were decapitated after 8 weeks, and their heart tissues were taken and examined. Lipid peroxidation by MDA (malondialdehyde) analyzes, GSH (glutathione) level and catalase activity were determined by spectrophotometer. Protein expression levels of caspase-3, caspase-6, caspase-9, Bcl-2, Bax, BDNF, GSK-3, Nrf-2 and NF-κB proteins in heart tissue were determined by western blotting technique and hearth tissueevaluated by histopathologically. As a result, MDA levels, Bcl-2, GSK-3 and NF-κB protein expression levels were reduced, whereas GSH levels, caspase-3, caspase-9, caspase-6, Bax, BDNF and Nrf-2 protein levels were increased in the F50 + RJ and F100 + RJ groups compared to the F50 and F100 groups.According to the results of this study, it has been concluded that Royal jelly has the potential to be developed into a drug for treatment of heart diseases in addition to providing protection against heart damage.

Study Type : Animal Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.