Article Publish Status: FREE
Abstract Title:

Royal Jelly Alleviates Cognitive Deficits andβ-Amyloid Accumulation in APP/PS1 Mouse Model Via Activation of the cAMP/PKA/CREB/BDNF Pathway and Inhibition of Neuronal Apoptosis.

Abstract Source:

Front Aging Neurosci. 2018 ;10:428. Epub 2019 Jan 4. PMID: 30687079

Abstract Author(s):

Mengmeng You, Yongming Pan, Yichen Liu, Yifan Chen, Yuqi Wu, Juanjuan Si, Kai Wang, Fuliang Hu

Article Affiliation:

Mengmeng You


Alzheimer's disease (AD) is characterized clinically by progressive cognitive decline and pathologically by the accumulation of amyloid-β (Aβ) in the brain. Royal jelly (RJ), a secretion of honeybee hypopharyngeal and mandibular glands, has previously been shown to have anti-aging and neuromodulatory activities. In this study, we discovered that 3 months of RJ treatment substantially ameliorated behavioral deficits of APP/PS1 micein the Morris Water Maze (MWM) test and step-down passive avoidance test. Our data also showed that RJ significantly diminished amyloid plaque pathology in APP/PS1 mice. Furthermore, RJ alleviated c-Jun N-terminal kinase (JNK) phosphorylation-induced neuronal apoptosis by suppressing oxidative stress. Importantly, hippocampal cyclic adenosine monophosphate (cAMP), p-PKA, p-CREB and BDNF levels were significantly increased in the APP/PS1 mice after RJ treatment, indicating that the cAMP/PKA/CREB/BDNF pathway might be related to the ameliorative effect of RJ on cognitive decline. Collectively,these results provide a scientific basis for using RJ as a functional food for targeting AD pathology.

Study Type : Animal Study

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