Article Publish Status: FREE
Abstract Title:

Royal Jelly and its dual role in TNBS colitis in mice.

Abstract Source:

ScientificWorldJournal. 2015 ;2015:956235. Epub 2015 Mar 2. PMID: 25821860

Abstract Author(s):

Luis Paulo Manzo, Felipe Meira de-Faria, Ricardo José Dunder, Eduardo Augusto Rabelo-Socca, Silvio Roberto Consonni, Ana Cristina Alves de Almeida, Alba Regina Monteiro Souza-Brito, Anderson Luiz-Ferreira

Article Affiliation:

Luis Paulo Manzo

Abstract:

Royal Jelly (RJ) is widely consumed in diets throughout the world due to its beneficial effects: antioxidant, antitumor and anti-inflammatory. We have investigated the role of RJ in the development of TNBS colitis in mice. Colitis was induced by a rectal instillation of TNBS at 0.1 mL per mouse. Intestine samples of the animals orally treated with RJ (100, 150, and 200 mg/kg) were collected for antioxidant assays (GSH and GSH-Px), proinflammatory protein quantification (COX-2 and NF-κB), and histological analyses. RJ 100 mg/kg maintained GSH levels and increased the activity of GSH-Px, downregulated key inflammatory mediators (COX-2 and NF-κB), and decreased the lesions caused by TNBS as shown by the histological analyses. In conclusion, RJ showed anti-inflammatory and antioxidant properties in experimental colitis, resulting in the amelioration of the macroscopic and histological analyses. These results corroborate with the RJ supplementation in diets.

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