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Abstract Title:

Evaluation of the Bioactivities ofL. Leaves and Root Extracts Using Toxicity, Antimicrobial, and Antiparasitic Assays.

Abstract Source:

Evid Based Complement Alternat Med. 2019 ;2019:6825297. Epub 2019 Oct 30. PMID: 31827556

Abstract Author(s):

Oladayo Amed Idris, Olubunmi Abosede Wintola, Anthony Jide Afolayan

Article Affiliation:

Oladayo Amed Idris

Abstract:

Traditional folks in different parts of the world useL. for the treatment of microbial infections, malaria, and sleeping sickness in the form of decoction or tincture. In the search for a natural alternative remedy, this study aimed to evaluate the antimicrobial, antitrypanosomal, and antiplasmodial efficacy and the toxicity ofextracts. Antimicrobial potency of the extracts was evaluated using the agar dilution method to determine the minimum inhibitory concentration (MIC). The antitrypanosomal activity of the extracts was evaluated with themodel while the antimalaria potency was tested using3D7 strain. Toxicity was then tested with brine shrimp assay and cytotoxicity (HeLa cells). The acetone extract of the root (RT-ACE) reveals the highest antimicrobial potency with the lowest MIC value of<1.562 mg/mL for all bacteria strains and also showed high potent against fungi. RT-ACE (IC: 13 g/mL) and methanol extract of the leaf (LF-MEE; IC: 15 g/mL) show a strong inhibition ofThe ethanol extract of the root (RT-ETE: IC: 9.7 g/mL) reveals the highest inhibition ofparasite. RT-ETE and RT-ACE were found to have the highest toxicity in brine shrimp lethality assay (BSLA) and cytotoxicity which correlates in the two assays. This research revealedhas potency against microorganisms,, andand could be a potential source for the treatment of these diseases.

Study Type : In Vitro Study

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Sayer Ji
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