Abstract Title:

Estrogen levels in nipple aspirate fluid and serum during a randomized soy trial.

Abstract Source:

Cancer Epidemiol Biomarkers Prev. 2011 Jul 8. Epub 2011 Jul 8. PMID: 21742946

Abstract Author(s):

Gertraud Maskarinec, Nicholas J Ollberding, Shannon M Conroy, Yukiko Morimoto, Ian S Pagano, Adrian A Franke, Elisabet Gentzschein, Frank Z Stanczyk

Article Affiliation:

1Cancer Center, University of Hawaii.

Abstract:

Background. Based on the hypothesized protective effect, we examined the effect of soy foods on estrogens in nipple aspirate fluid (NAF) and serum, possible indicators of breast cancer risk. Methods. In a cross-over design, we randomized 96 women who produced≥10 µL NAF to a high- or low-soy diet for 6-months. During the high-soy diet, participants consumed 2 soy servings of soy milk, tofu, or soy nuts (approximately 50 mg of isoflavones/day); during the low-soy diet, they maintained their usual diet. Six NAF samples were obtained using a FirstCyte©Aspirator. Estradiol (E2) and estrone sulfate (E1S) were assessed in NAF and estrone (E1) in serum only using highly sensitive radioimmunoassays. Mixed-effects regression models accounting for repeated measures and left-censoring limits were applied. Results. Mean E2 and E1S were lower during the high-soy than the low-soy diet (113 vs. 313 pg/mL and 46 vs. 68 ng/mL, respectively) without reaching significance (p=0.07); the interaction between group and diet and was not significant. There was no effect of the soy treatment on serum E2 (p=0.76), E1 (p=0.86), or E1S (p=0.56). Within individuals,NAF and serum levels of E2 (rs=0.37; p<0.001) but not E1S (rs=0.004; p=0.97) were correlated. E2 and E1S in NAF and serum were strongly associated (rs=0.78 and rs=0.48; p<0.001). Conclusions. Soy foods in amounts consumed by Asians did not significantly modify estrogen levels in NAF and serum. Impact. The trend towards lower estrogens in NAF during the high-soy diet counters concerns about adverse effects of soy foods on breast cancer risk.

Study Type : Human Study

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