Abstract Title:

Safety evaluation of saffron (Crocus sativus) tablets in healthy volunteers.

Abstract Source:

Arch Dis Child. 2009 Oct;94(10):801-5. Epub 2009 Jun 24. PMID: 18693099

Abstract Author(s):

Mohammad-Hadi Modaghegh, Masoud Shahabian, Habib-Allah Esmaeili, Omid Rajbai, Hossein Hosseinzadeh


Saffron (Crocus sativus) stigma tablets were evaluated for short-term safety and tolerability in healthy adult volunteers. The study was a double-blind, placebo-controlled design consisting of a 1 week treatment of saffron tablets. Volunteers were divided into 3 groups of 10 each (5 males and 5 females). Group I received placebo; groups 2 and 3 received 200 and 400mg saffron tablets, respectively, for 7 days. General measures of health were recorded during the study such as hematological, biochemical and electrocardiographic parameters done in pre- and post-treatment periods. Clinical examination showed no gross changes in all volunteers after intervention. Saffron with higher dose (400mg) decreased standing systolic blood pressure and mean arterial pressures significantly. Saffron decreased slightly some hematological parameters such as red blood cells, hemoglobin, hematocrit and platelets. Saffron increased sodium, blood urea nitrogen and creatinine. This study showed that saffron tablets may change some hematological and biochemical parameters. However, these alterations were in normal ranges and they were not important clinically.

Study Type : Human Study
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