n/a
Abstract Title:

Salvianolic acid A ameliorates renal ischemia/reperfusion injury by activating Akt/mTOR/4EBP1 signaling pathway.

Abstract Source:

Am J Physiol Renal Physiol. 2018 Jan 31. Epub 2018 Jan 31. PMID: 29384417

Abstract Author(s):

Ying Song, Weihai Liu, Yi Ding, Yan-Yan Jia, Jinyi Zhao, Fan Wang, Juan Bai, Lianghua Cheng, Kai Gao, Meiyou Liu, Minna Yao, Liang Li, Yanmin Zhang, Aidong Wen, Langchong He

Article Affiliation:

Ying Song

Abstract:

Salvianolic acid A (Sal A) has been shown to prevent and treat ischemic cardiovascular as well as cerebral vascular diseases. However, little is known about Sal A in renal ischemia/reperfusion (I/R) injury. In this study, a renal I/R injury model in rats and a hypoxia/reoxygenation (H/R) model to damage proximal renal tubular cells (HK-2) were used to assess whether Sal A halts the development and progression of renal I/R injury. As compared to vehicle treatment, Sal A significantly attenuated kidney injury and lowered plasma creatinine, blood urea nitrogen levels, the number of apoptosis-positive tubular cells, and kidney oxidative stress after renal I/R injury. In addition, Sal A also activated phosphorylated-protein kinase B (p-Akt) and phosphorylated-mammalian target of rapamycin (p-mTOR) compared to vehicle-treated I/R injury rats. In H/R injury HK-2 cells, Sal A can reduce the levels of reactive oxygen species (ROS) in a dose-related manner. Sal A also increased the protein expression of phosphorylated-eukaryotic initiation factor 4E binding protein 1 (p-4EBP1) compared to vehicle. Furthermore, the cytoprotective activity of Sal A was inhibited by these two LY294002 and rapamycin. These findings indicate that Sal A may ameliorate renal I/R injury and promote tubular cell survival via the Akt/mTOR/4EBP1pathway and Sal A could be a candidate compound for the prevention of ischemic tissue damage.

Study Type : Animal Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.