Abstract Title:

Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines.

Abstract Source:

J Nat Med. 2016 May 13. Epub 2016 May 13. PMID: 27178360

Abstract Author(s):

Kiyofumi Ninomiya, Chiaki Motai, Eriko Nishida, Niichiro Kitagawa, Kazuya Yoshihara, Takao Hayakawa, Osamu Muraoka, Xuezheng Li, Seikou Nakamura, Masayuki Yoshikawa, Hisashi Matsuda, Toshio Morikawa

Article Affiliation:

Kiyofumi Ninomiya


Seven oleanane-type triterpene saponin bisdesmosides, perennisaponins N-T (1-7), were newly isolated from a methanol extract of daisy, the flowers of Bellis perennis L. (Asteraceae). The structures were determined based on chemical and physicochemical data and confirmed using previously isolated related compounds as references. The isolates, including 13 previously reported perennisaponins A-M (8-20), exhibited anti-proliferative activities against human digestive tract carcinoma HSC-2, HSC-4, and MKN-45 cells. Among them, perennisaponin O (2, IC50 = 11.2, 14.3, and 6.9 μM, respectively) showed relatively strong activities. The mechanism of action of 2 against HSC-2 was found to involve apoptotic cell death.

Study Type : In Vitro Study

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