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Abstract Title:

[Screening, identification and activity evaluation of pancreatic lipase inhibition in Prunella vulgaris].

Abstract Source:

Zhongguo Zhong Yao Za Zhi. 2018 Dec ;43(23):4665-4671. PMID: 30717556

Abstract Author(s):

Ting-Gui Chen, Li-Ya Li, Yu-Ru Wei, Li-Wei Zhang

Article Affiliation:

Ting-Gui Chen

Abstract:

Pancreatic lipase (PL) inhibitors were firstly screened from Prunella vulgaris with PL immobilized on carboxylic acid-terminated magnetic nanoparticles, then these possible inhibitors were identified by LC-MS/MS and mixed standards. Finally, their inhibitory effects and types on PL were tested by p-nitrophenol method. The results showed that four PL inhibitors were screened out from P. vulgaris and confirmed by LC-MS/MS and mixed standards. The IC₅₈ and inhibition types were as follows: caffeic acid [(252.3±3.6) mg·L⁻¹, anti-competitive inhibition], rutin [(91.2±1.6)mg·L⁻¹, competitive inhibition], hesperidin [(31.5±4.4) mg·L⁻¹, competitive inhibition] and ursolic acid [(41.3±2.2) mg·L⁻¹, competitive inhibition]. Their inhibitive types and abilities on PL were related to their molecular size, hydrophobicity and the number of hydrogen bond with PL triplet.

Study Type : In Vitro Study

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Sayer Ji
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