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Abstract Title:

Seabuckthron (Hippophae rhamnoides L.) leaf extract ameliorates the gamma radiation mediated DNA damage and hepatic alterations.

Abstract Source:

Indian J Exp Biol. 2014 Oct ;52(10):952-64. PMID: 25345244

Abstract Author(s):

Amitava Khan, Krishnendu Manna, Chinchubose, Dipesh Kr Das, Mahuya Sinha, Swaraj Bandhu Kesh, Ujjal Das, Rakhi Sharma Dey, Asoke Banerji, Sanjit Dey

Article Affiliation:

Amitava Khan

Abstract:

In vitro assessment showed that H. rhamnoides (HrLE) extract possessed free radical scavenging activities and can protect gamma (gamma) radiation induced supercoiled DNA damage. For in vivo study, Swiss albino mice were administered with HrLE (30 mg/kg body weight) for 15 consecutive days before exposing them to a single dose of 5 Gy of beta radiation. HrLE significantly prevented the radiation induced genomic DNA damage indicated as a significant reduction in the comet parameters. The lipid peroxidation, liver function enzymes, expression of phosphorylated NFkappaB (p65) and IkappaBalpha increased whereas the endogenous antioxidants diminished upon radiation exposure compared to control. Pretreatment of HrLE extract ameliorated these changes. Based on the present results it can be concluded that H. rhamnoides possess a potential preventive element in planned and accidental nuclear exposures.

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