Abstract Title:

The inhibitory effect of the crude extract from a seaweed of Dygenea simplex C. Agardh on the in vitro cytopathic activity of HIV-1 and it's antigen production.

Abstract Source:

Chem Pharm Bull (Tokyo). 1995 Sep;43(9):1580-4. PMID: 7586085

Abstract Author(s):

H Sekine, N Ohonuki, K Sadamasu, K Monma, Y Kudoh, H Nakamura, Y Okada, T Okuyama

Article Affiliation:

Department of Microbiology, Tokyo Metropolitan Research Laboratory of Public Health, Japan.


The crude water extract (NS-1) from a seaweed (Digenea simplex C. Agardh Rhodomelaceae) exhibited anti-human immunodeficiency virus (HIV)-1 activity in vitro. The inhibitory effect of the extract on the cytopathic activity of HIV-1 and it's antigen production was examined using a microplate method, immunofluorescent assay, and an HIV antigen detection kit (Abbott). NS-1 inhibited both the cytopathic effect of HIV-1 to MT-4 cells and the giant cell formation of Molt-4 cells infected with HIV-1.

Study Type : In Vitro Study

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