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Abstract Title:

Antibacterial Activity of Passion Fruit Purple Variant () Seeds Extract Against.

Abstract Source:

Clin Cosmet Investig Dermatol. 2020 ;13:99-104. Epub 2020 Jan 31. PMID: 32099437

Abstract Author(s):

Nelva K Jusuf, Imam Budi Putra, Nani Kumala Dewi

Article Affiliation:

Nelva K Jusuf


Background: Passion fruit is used commercially for consumption and in beverages. This plant exhibits various pharmacological properties and possesses a complex phytochemistry. In recent years, this plant has been shown to have potential antimicrobial activity. The seeds contain a high amount of piceatannol, which exhibits an inhibitory effect on. Therefore, the seed extract of purple variant,, may have potential antibacterial activity against.

Aim: To evaluate the antibacterial activity ofseeds extract on

Methods: Seed extract was prepared by maceration and dissolved in DMSO in multiple concentrations.was cultured inblood sheep 5% agar for 24 hours and the agar disc diffusion method was used to evaluate the inhibitory effect of each concentration (1.25%, 2.5%, 5%, 10%, 20%, and 40%), in comparison with clindamycin and erythromycin. Zones of inhibition at 24 hours were measured and documented, then analyzed to obtain the mean inhibition zone (MIZ). The Mann-Whitney test was conducted to compare the antibacterial activity of the extract, clindamycin and erythromycin. A serial dilution assay of five different concentrations (5%, 10%, 15%, 20%, and 25%) in brain-heart infusion broth was performed to determine the minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC).

Results: After 24 hours, all concentrations ofshowed an inhibitory effect against, with MIZs for of each concentration of 1.25% 6 mm, 2.5% 6.83 mm, 5% 8.5 mm, 10% 10.08 mm, 20% 14 mm, and 40% 16 mm. Clindamycin revealed comparable antibacterial effect to 5% seed extract, with an MIZ of 8 mm. However, erythromycin was found to be superior to the seed extract, with a 22.67 mm MIZ (<0.05). The serial dilution assay revealed an MIC of 20% and MBC of 25%.

Conclusion: Seed extract ofhad good antibacterial activity against, and the effect increased with the concentration.

Study Type : In Vitro Study
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