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Abstract Title:

Selenium enrichment improves anti-proliferative effect of oolong tea extract on human hepatoma HuH-7 cells.

Abstract Source:

Food Chem Toxicol. 2021 Jan ;147:111873. Epub 2020 Nov 26. PMID: 33248145

Abstract Author(s):

Qi Wang, Xuefang Guan, Chengchun Lai, Huiying Gao, Yafeng Zheng, Juqing Huang, Bin Lin

Article Affiliation:

Qi Wang

Abstract:

Selenium (Se)-enriched tea is attracting increasing interests due to its significantly improved health benefits. This study was to investigate the anti-proliferative effects of Se-enriched oolong tea against human hepatoma HuH-7 cells. Compared with regular oolong tea extract (TE, 0.04 μg selenium/g), Se-enriched oolong tea extract (Se-TE, 0.51 μg selenium/g) exhibited more prominent anti-proliferative effect against HuH-7 cells with an ICof 203.1 μg/mL, mainly due to the synergistic effects of organic selenium and tea polyphenols. Our results found that Se-TE increased intracellular ROS production, arrested the cell cycle at G2/M phase, and thus induced cell apoptosis. In addition, western blotting assay revealed the increased expressionsof the p53, Bax, caspase 3, and a reduction of Bcl-2 and CDK2, resulting in Se-TE-induced apoptosis. The improved anti-proliferative effect makes Se-enriched oolong tea extract a promising health-promoting ingredient in food industry.

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