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Abstract Title:

Glutathione peroxidase in amyotrophic lateral sclerosis: the effects of selenium supplementation.

Abstract Source:

Scand J Rheumatol. 1995;24(2):85-93. PMID: 9726810

Abstract Author(s):

S Apostolski, Z Marinković, A Nikolić, D Blagojević, M B Spasić, A M Michelson

Article Affiliation:

Institute of Neurology, School of Medicine, University of Belgrade, Yugoslavia.

Abstract:

The activity of glutathione peroxidase (GSH-Px) as well as the activities of other antioxidative enzymes: CuZn superoxide dismutase (CuZn SOD), catalase (CAT), glutathione reductase (GR) in erythrocytes, as well as the activity of plasma glutathione transferase (GST), and the plasma content of vitamins E and C were evaluated in 35 sporadic amyotrophic lateral sclerosis (sALS) patients. The results revealed significantly decreased activity of both GSH-Px and CuZn SOD in sALS patients compared with the control. These data showed that a disturbed oxidative/antioxidative balance in sALS patients exists not only in motoneurons but also in the blood. The effect of exogenously administered selenium (Se), antioxidants, amino acids, a Ca2+ channel blocker such as nimodipine, and their combination in Alsamin was evaluated by screening parameter levels after 9 weeks of treatment. Only the use of all components together enhanced the activity of GSH-Px and the amount of vitamin E in sALS patients. Judging by the results of clinical trials, this treatment slowed the course of the disease.

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Sayer Ji
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