Abstract Title:

Vitamin D predictors in polycystic ovary syndrome: A meta-analysis.

Abstract Source:

Eur J Clin Invest. 2017 Aug 10. Epub 2017 Aug 10. PMID: 28795765

Abstract Author(s):

Flora Bacopoulou, Evangelia Kolias, Vasiliki Efthymiou, Constantine N Antonopoulos, Evangelia Charmandari

Article Affiliation:

Flora Bacopoulou


BACKGROUND: The aim of this meta-analysis was to examine differences and predictors of serum 25-hydroxyvitamin D concentrations in women with polycystic ovary syndrome (PCOS) compared with non-PCOS controls matched for body mass index.

MATERIALS AND METHODS: Three databases were searched (2003-2015) to retrieve studies that evaluated serum 25-hydroxyvitamin D in PCOS women and controls. Meta-regression analysis was performed with anthropometric and metabolic/endocrine parameters as covariates.

RESULTS: Fourteen studies that included 2,262 women (1,150 PCOS patients/1,162 controls) were eligible. Serum 25-hydroxyvitamin D, follicle stimulating hormone and sex hormone-binding globulin were significantly lower in PCOS patients than controls. Homeostatic model assessment-insulin resistance index, serum insulin, total cholesterol, triglycerides, low-density lipoprotein cholesterol, luteinizing hormone and testosterone were significantly higher in PCOS patients compared to controls. Meta-regression analysis demonstrated significant effects of waist-to-hip ratio and glucose in PCOS women (β = -1.60, 95% CI: -2.30 to -0.90, P=0.003; β = 0.20, 95% CI: 0.80 to 0.32, P=0.004, respectively) and controls (β = -2.36, 95% CI: -3.38 to -1.33, P=0.003; β = 0.11, 95% CI: 0.00 to 0.21, P=0.05, respectively) and of total calcium and luteinizing hormone in PCOS cases (β = 2.43, 95% CI: 1.67 to 3.19, P=0.005; β = -0.37, 95% CI: -0.68 to -0.06, P=0.03, respectively).

CONCLUSIONS: Serum 25-hydroxyvitamin D may be predicted positively by serum calcium and negatively by luteinizing hormone in women with PCOS, and negatively by waist-to-hip ratio and positively by fasting glucose in both PCOS and non-PCOS women, independently of the presence of obesity. This article is protected by copyright. All rights reserved.

Study Type : Meta Analysis

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.