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Article Publish Status: FREE
Abstract Title:

High Levels of miR-483-3p Are Present in Serum Exosomes Upon Infection of Mice With Highly Pathogenic Avian Influenza Virus.

Abstract Source:

Front Microbiol. 2020 ;11:144. Epub 2020 Feb 11. PMID: 32117163

Abstract Author(s):

Tadashi Maemura, Satoshi Fukuyama, Yoshihiro Kawaoka

Article Affiliation:

Tadashi Maemura

Abstract:

Exosomes, the extracellular vesicles that contain functional proteins and RNAs, regulate cell-cell communication. Recently, our group reported that levels of various microRNAs (miRNAs) in bronchoalveolar lavage fluid exosomes were highly increased in influenza virus-infected mice and that one of those miRNAs, miR-483-3p, was involved in the potentiation of the innate immune responses to influenza virus infection in mouse type II pneumocytes. Here, we evaluated exosomal miR-483-3p levels in the serum of influenza virus-infected mice and found that miR-483-3p levels were significantly increased during infection with a highly pathogenic avian H5N1 influenza virus. Moreover, miR-483-3p-enriched exosomes derived from type II pneumocytes potentiated the expression of proinflammatory cytokine genes in vascular endothelial cells. Our findings suggest that serum exosomal transfer of miR-483-3p might be involved in the inflammatory pathogenesis of H5N1 influenza virus infection.

Study Type : Animal Study
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Additional Keywords : Exosomes : CK(35) : AC(10)

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Sayer Ji
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