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Article Publish Status: FREE
Abstract Title:

ASSOCIATION OF VITAMIN D WITH MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DEMENTIA IN OLDER MEXICAN ADULTS.

Abstract Source:

Rev Invest Clin. 2019 ;71(6):381-386. PMID: 31823966

Abstract Author(s):

Sara G Aguilar-Navarro, Alberto J Mimenza-Alvarado, Gilberto A Jiménez-Castillo, Leonardo A Bracho-Vela, Sara G Yeverino-Castro, José A Ávila-Funes

Article Affiliation:

Sara G Aguilar-Navarro

Abstract:

Background: It has been proposed that Vitamin D helps reduce the accumulation of cerebralβ-amyloid-42 by innate immune stimulation and phagocytosis activation. An association between low Vitamin D levels and Alzheimer's dementia (AD) has been established. We determined the association between Vitamin D, mild cognitive impairment (MCI), and AD in older Mexican adults (>65 years).

Methods: Cross-sectional study conducted at the memory clinic in a tertiary-level hospital in Mexico City. We evaluated subjects with MCI, AD, and normal cognition (NC) with available serum Vitamin D [25(OH)D] levels (past 6 months). Three categories were assigned according to 25(OH)D levels: sufficiency (>30 ng/mL), insufficiency (21-29 ng/mL), and deficiency (≤ 20 ng/mL). Descriptive statistics, means and standard deviations were used. Logistic regression analyses adjusted by age, sex, and educational level were performed.

Results: We evaluated 208 patients. Mean age was 79± 1 year, 65% (n = 136) were female; and mean educational level was 6.7 ± 2.3 years. Thirty-one subjects (14%) had NC; 42% (n = 88) had MCI; and 43% (n = 89) had AD. Prevalence of Vitamin D deficiency was 54%, more frequent in the AD group (64%) followed by the MCI (59%) and NC (13%) (p<0.001) groups. In the multivariate logistic regression analysis, Vitamin D deficiency was associated with MCI (HR 25.02 [confidence interval 95% 4.48-139]; p<0.001) and AD (HR 41.7 [5.76-301]; p<0.001) after adjusting for confounders.

Conclusions: Serum Vitamin D deficiency was associated with MCI and dementia; low levels produced a greater effect over executive functions.

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