Article Publish Status: FREE
Abstract Title:

Influence of serum vitamin D level on Helicobacter pylori eradication: A multi-center, observational, prospective and cohort study.

Abstract Source:

J Dig Dis. 2019 Aug ;20(8):421-426. Epub 2019 Jul 3. PMID: 31145549

Abstract Author(s):

Chuan Han, Zhen Ni, Ting Yuan, Jian Zhang, Chan Wang, Xin Wang, Han Bing Ning, Jie Liu, Nina Sun, Cai Fang Liu, Miao Shi, Wen Quan Lu, Yong Quan Shi

Article Affiliation:

Chuan Han


OBJECTIVES: This study was designed to test whether serum vitamin D levels affected Helicobacter pylori (H. pylori) infection and eradication rates.

METHODS: A multicenter observational prospective cohort study was conducted. A total of 496 H. pyloripositive (H. pylori) and 257 H. pylori-negative (H. pylori) patients were enrolled from four hospitals in China. Baseline serum vitamin D levels were measured and aC-urea breath test (UBT) was performed for all the participants. The H. pyloripatients were divided into two subgroups based on their serum vitamin D levels (<10 or≥10 ng/mL). A secondC-UBT was performed between 4 and 8 weeks after 14-day bismuth-containing quadruple eradication therapies. Factors potentially affecting H. pylori eradication were determined using a questionnaire survey.

RESULTS: Serum vitamin D levels were significantly lower in the H. pylorigroup than in the H. pylorigroup ([17.0 ± 6.9] ng/mL vs [19.2 ± 8.0] ng/mL, P = 0.000). H. pylori eradication rate significantly differed between patients with serum vitamin D levels of<10 ng/mL and≥10 ng/mL (71.7% vs 87.3%, P = 0.005). A multivariate analysis showed that having serum vitamin D level ≥10 ng/mL was an independent risk factor for a successful H. pylori eradication (odds ratio 0.381, 95% confidence interval 0.183-0.791, P = 0.010).

CONCLUSIONS: Serum vitamin D level may affect H. pylori infection and its eradication. Randomized controlled trials are needed to find out whether vitamin D supplements may increase the H. pylori eradication rate.

Study Type : Human Study

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Sayer Ji
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