Serum vitamin D level may affect H. pylori infection and its eradication. - GreenMedInfo Summary
Influence of serum vitamin D level on Helicobacter pylori eradication: A multi-center, observational, prospective and cohort study.
J Dig Dis. 2019 Aug ;20(8):421-426. Epub 2019 Jul 3. PMID: 31145549
OBJECTIVES: This study was designed to test whether serum vitamin D levels affected Helicobacter pylori (H. pylori) infection and eradication rates.
METHODS: A multicenter observational prospective cohort study was conducted. A total of 496 H. pyloripositive (H. pylori) and 257 H. pylori-negative (H. pylori) patients were enrolled from four hospitals in China. Baseline serum vitamin D levels were measured and aC-urea breath test (UBT) was performed for all the participants. The H. pyloripatients were divided into two subgroups based on their serum vitamin D levels (<10 or≥10 ng/mL). A secondC-UBT was performed between 4 and 8 weeks after 14-day bismuth-containing quadruple eradication therapies. Factors potentially affecting H. pylori eradication were determined using a questionnaire survey.
RESULTS: Serum vitamin D levels were significantly lower in the H. pylorigroup than in the H. pylorigroup ([17.0 ± 6.9] ng/mL vs [19.2 ± 8.0] ng/mL, P = 0.000). H. pylori eradication rate significantly differed between patients with serum vitamin D levels of<10 ng/mL and≥10 ng/mL (71.7% vs 87.3%, P = 0.005). A multivariate analysis showed that having serum vitamin D level ≥10 ng/mL was an independent risk factor for a successful H. pylori eradication (odds ratio 0.381, 95% confidence interval 0.183-0.791, P = 0.010).
CONCLUSIONS: Serum vitamin D level may affect H. pylori infection and its eradication. Randomized controlled trials are needed to find out whether vitamin D supplements may increase the H. pylori eradication rate.