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Abstract Title:

Sesamin Catechol Glucuronides Exert Anti-inflammatory Effects by Suppressing Interferonβ and Inducible Nitric Oxide Synthase Expression through Deconjugation in Macrophage-like J774.1 Cells.

Abstract Source:

J Agric Food Chem. 2019 Jul 10 ;67(27):7640-7649. Epub 2019 Apr 16. PMID: 30951310

Abstract Author(s):

Naomi Abe-Kanoh, Yumi Kunimoto, Daisuke Takemoto, Yoshiko Ono, Hiroshi Shibata, Kohta Ohnishi, Yoshichika Kawai

Article Affiliation:

Naomi Abe-Kanoh

Abstract:

Sesamin, a representative sesame lignan, has health-promoting activities. Sesamin is converted into catechol derivatives and further into their glucuronides or sulfates, whereas the biological activities of sesamin metabolites remain unclear. We examined the inhibitory effects of sesamin metabolites on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse macrophage-like J774.1 cells and found that a monocatechol derivative SC1, (7α,7'α,8α,8'α)-3,4-dihydroxy-3',4'-methylenedioxy-7,9':7',9-diepoxylignane, has a much higher activity than sesamin and other metabolites. The inhibitory effects of SC1 glucuronides were time-dependently enhanced, associated with the intracellular accumulation of SC1 and the methylated form. SC1glucuronides and SC1 attenuated the expression of inducible NO synthase (iNOS) and upstream interferon-β (IFN-β) in the LPS-stimulated macrophages. The inhibitory effects of SC1 glucuronides against NO production were canceled by the β-glucuronidase inhibitor and enhanced by the catechol--methyltransferase inhibitor. Our results suggest that SC1 glucuronides exert the anti-inflammatory effects by inhibiting the IFN-β/iNOS signaling through macrophage-mediated deconjugation.

Study Type : In Vitro Study

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