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Abstract Title:

Sesamin suppresses advanced glycation end products induced microglial reactivity using BV2 microglial cell line as a model.

Abstract Source:

Brain Res Bull. 2021 Apr 21 ;172:190-202. Epub 2021 Apr 21. PMID: 33894297

Abstract Author(s):

Sasimol Udomruk, Benjawan Wudtiwai, Thuzar Hla Shwe, Thanyaluck Phitak, Peraphan Pothacharoen, Mattabhorn Phimphilai, Prachya Kongtawelert

Article Affiliation:

Sasimol Udomruk

Abstract:

Neuroinflammation-mediated microglial reactivity is a major process, which explains the increased risk of Alzheimer's disease (AD) development in patients with Type 2 diabetes mellitus (T2DM). Advanced glycation end products (AGEs), formed by hyperglycemic condition in diabetes, is characterized as an intermediary of brain injury with diabetes through induction of microglial reactivity. Here, we explored the effect of AGEs on microglial reactivity using BV2 as a model. The NF-κB, p38 and JNK pathways were found to be important mechanism in AGEs-induced BV2 microglial reactivity. NF-κB inhibitor (BAY-11-7082), p38 inhibitor (SB203580) and JNK inhibitor (SP600125) exhibited the potential inhibition of AGEs-induced NO production. We also found that the sesamin, a major lignan found in sesame seed oils, exerts an anti-inflammatory effect under AGEs-induced microglial reactivity via suppressing the phosphorylation of NF-κB, p38 and JNK pathways. Moreover, sesamin also ameliorated AGEs-induced-receptor for advanced glycation end products (RAGE) expression. Taken together, sesamin may be a promising phytochemical compound to delay inflammatory progress by AGEs microglia function. Similarly, inhibition of AGEs-induced microglial reactivity might be potential therapeutic targets of neuroinflammation-based mechanisms in T2DM link progressive AD.

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