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Abstract Title:

Sesamol attenuates oxidative stress-mediated experimental acute pancreatitis in rats.

Abstract Source:

Hum Exp Toxicol. 2012 Apr ;31(4):397-404. Epub 2011 Nov 10. PMID: 22076497

Abstract Author(s):

P-Y Chu, P Srinivasan, J-F Deng, M-Y Liu

Article Affiliation:

P-Y Chu

Abstract:

Acute pancreatitis is a potentially fatal disease with no known cure. The initial events in acute pancreatitis may occur within the acinar cells. We examined the effect of sesamol on (i) a cerulein-induced pancreatic acinar cancer cell line, AR42J, and (ii) cerulein-induced experimental acute pancreatitis in rats. Sesamol inhibited amylase activity and increased cell survival. It also inhibited medium lipid peroxidation and 8-hydroxydeoxyguanosine in AR42J cells compared with the cerulein-alone groups. In addition, in cerulein-treated rats, sesamol inhibited serum amylase and lipase levels, pancreatic edema, and lipid peroxidation, but it increased pancreatic glutathione and nitric oxide levels. Thus, we hypothesize that sesamol attenuates cerulein-induced experimental acute pancreatitis by inhibiting the pancreatic acinar cell death associated with oxidative stress in rats.

Study Type : Animal Study

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Sayer Ji
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