Abstract Title:

Sesamol down-regulates the lipopolysaccharide-induced inflammatory response by inhibiting nuclear factor-kappa B activation.

Abstract Source:

Innate Immun. 2010 Oct ;16(5):333-9. Epub 2009 Nov 25. PMID: 19939906

Abstract Author(s):

Pei-Yi Chu, Dur-Zong Hsu, Pin-Yen Hsu, Ming-Yie Liu

Article Affiliation:

Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan.

Abstract:

We examined the effects of sesamol on the lipopolysaccharide (LPS)-induced inflammatory response. Sesamol inhibited serum tumor necrosis factor (TNF)-α, interleukin (IL)-1β and nitrite production in LPS-treated mice, and inhibited LPS-induced inducible nitric oxide synthase expression in mouse leukocytes. Sesamol also down-regulated TNF-α, IL-1β, and nitrite production as well as inducible nitric oxide synthase expression in LPS-treated RAW 264.7 cells. Further, sesamol inhibited LPS-induced nuclear factor (NF)-κB translocation and inhibitor (I)κB-α phosphorylation in RAW 264.7 cells. By inhibiting TNF-α, IL-1β, and nitrite levels, and interfering with the NFκB pathway, sesamol down-regulated the LPS-initiated inflammatory response.

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