Abstract Title:

Chondroprotective role of sesamol by inhibiting MMPs expression via retaining NF-κB signaling in activated SW1353 cells.

Abstract Source:

J Agric Food Chem. 2011 May 11 ;59(9):4969-78. Epub 2011 Mar 23. PMID: 21428299

Abstract Author(s):

Yung-Chang Lu, Thanasekaran Jayakumar, Yeh-Fang Duann, Yung-Chen Chou, Cheng-Ying Hsieh, Shin-Yun Yu, Joen-Rong Sheu, George Hsiao

Article Affiliation:

Department of Orthopaedic Surgery, Mackay Memorial Hospital, Department of Leisure Sports and Health Management, College of Humanities and Sciences, St. John's University, Taipei, Taiwan.

Abstract:

Overexpression of matrix metalloproteinases (MMPs) is a major pathological factor causing cartilage destruction in osteoarthritis (OA). This study aimed to investigate the effects and mechanisms of sesamol on expression of MMPs in activated chondrosarcoma cells. Sesamol significantly attenuated TNF-α- and IL-1β-induced gelatinolysis and expression of MMP-9 in a concentration-dependent manner in SW1353 cells. Additionally, both MMP-1 and -13 stimulated by PMA were inhibited by sesamol. On the other hand, the NF-κB signaling activation through IκB-α degradation was restored by sesamol underTNF-α or PMA stimulation. Furthermore, this bioactive compound exerted the reduction on phosphorylation of ERK1/2 or p38 MAPKs after either PMA or IL-1β stimulation. This study also evaluated whether sesamol down-regulates MMP expression in the joint cartilage of monosodium iodoacetate (MIA)-induced OA in rats. Sesamol prevented the expression of MMP-1 and -9 in the cartilage of MIA-induced OA in rats. The results of this study demonstrate that sesamol inhibits cytokine- or PMA-induced MMPs expression through the signal pathways of either NF-κB or ERK/p38 MAPKs down-regulation. This studyalso showed that sesamol attenuates destructive factor expression in vivo, providing a potential strategy for the chondroprotective therapy in OA.

Study Type : In Vitro Study

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