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Abstract Title:

Sesquiterpenoids from the roots of Inula helenium inhibit acute myelogenous leukemia progenitor cells.

Abstract Source:

Bioorg Chem. 2019 05 ;86:363-367. Epub 2019 Jan 31. PMID: 30753990

Abstract Author(s):

Yahui Ding, Wenwei Pan, Junqing Xu, Tianpeng Wang, Tianyang Chen, Zhongquan Liu, Chunfeng Xie, Quan Zhang

Article Affiliation:

Yahui Ding

Abstract:

One new eudesmane sesquiterpenoid, 11β-hydroxy-13-chloro-eudesm-5-en-12, 8-olide (1), was isolated from the roots of Inula helenium together with nine eudesmanolides (2-10) and one germacranolide (11). Their structures were elucidated on the basis of detailed spectroscopic analyses. All isolates were evaluated for their antiproliferative activities against human leukemia stem-like cell line KG1a. Compound 10 exhibited the most potent effect with the ICvalue of 3.36 ± 0.18 μM. A further investigation revealed that compound 10 could significantly induce apoptosis of KG1a cells. Additionally, compound 10 had an obvious effect on the levels of apoptosis-related proteins (Bcl-2, Bax, cytochrome c, caspase 9 and caspase 3), indicating that the antiproliferative effect of compound 10 on KG1a cells might be mediated through a mitochondria-dependent apoptotic pathway.

Study Type : In Vitro Study

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Sayer Ji
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