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Article Publish Status: FREE
Abstract Title:

In Vitro Wound Healing Potential of Stem Extract of.

Abstract Source:

Evid Based Complement Alternat Med. 2018 ;2018:3142073. Epub 2018 Feb 19. PMID: 29670658

Abstract Author(s):

Katyakyini Muniandy, Sivapragasam Gothai, Woan Sean Tan, S Suresh Kumar, Norhaizan Mohd Esa, Govindasamy Chandramohan, Khalid S Al-Numair, Palanisamy Arulselvan

Article Affiliation:

Katyakyini Muniandy

Abstract:

Impaired wound healing is one of the serious problems among the diabetic patients. Currently, available treatments are limited due to side effects and cost effectiveness. In line with that, we attempted to use a natural source to study its potential towards the wound healing process. Therefore,(), an edible and medicinal plant, was chosen as the target sample for the study. During this investigation, the wound closure properties using stem extract ofwere analyzed. Accordingly, we analyzed the extract on free radical scavenging capacity and the cell migration of two most prominent cell types on the skin, human dermal fibroblast (NHDF), keratinocytes (HaCaT), and diabetic human dermal fibroblast (HDF-D) to mimic the wound healing in diabetic patients. The bioactive compounds were identified using gas chromatography-mass spectrometry (GC-MS). We discovered that the analysis exhibited a remarkable antioxidant, proliferative, and migratory rate in NHDF, HaCaT, and HDF-D in dose-dependent manner, which supports wound healing process, due to the presence of wound healing associated phytocompounds such as Hexadecanoic acid. This study suggested that the stem extract ofmight be a potential therapeutic agent for skin wound healing, supporting its traditional medicinal uses.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antioxidants : CK(21528) : AC(8856)

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