n/a
Abstract Title:

Rubella specific cell-mediated and humoral immunity following vaccination in college students with low antibody titers.

Abstract Source:

Vaccine. 2015 Nov 9 ;33(45):6093-8. Epub 2015 Aug 12. PMID: 26275479

Abstract Author(s):

Kihei Terada, Yuri Itoh, Tokio Wakabayashi, Hideto Teranishi, Hiroto Akaike, Satoko Ogita, Kazunobu Ouchi

Article Affiliation:

Kihei Terada

Abstract:

OBJECTIVE: This study measured cell-mediated immunity (CMI) and antibodies to clarify the basis of rubella reinfection after vaccination.

METHODS: In a pool of 65 college students, 39 who exhibited hemagglutination-inhibition (HI) antibody titers against rubella of≤ 1:16 were vaccinated with a rubella vaccine. The CMI was assessed with interferon-gamma release assay.

RESULTS: There was low correlation (r = 0.24) between the antibody titers and interferon-gamma levels at pre-vaccination status. Preexisting interferon-gamma levels were low in some subjects with low HI antibody titers of 1:8 and 1:16. Fifty-seven percent (4/7) of the subjects who were antibody-negative with past history of rubella vaccination at entry onto the study exhibited CMI. And 57% (4/7) of the subjects remained antibody-negative following a second vaccination, despite exhibiting CMI. HI antibody titers increased significantly after vaccination, whereas post-vaccination interferon-gamma levels did not exhibit significant increases. When subjects were divided (based on their past history of vaccination and antibody values) into natural infection and vaccination groups, HI antibody titers (mean± SD) increased to 1:2(4.4 ± 1.4) from 1: 2(3.2 ± 0.4) (p = 0.065) in the natural infection group and to 1:2(4.4 ± 1.0) from 1:2(3.0 ± 0.8) (p<0.00001) in the vaccination group following vaccination. The same classification revealed that interferon-gamma values did not increase significantly in either group following vaccination, but the interferon-gamma values at pre- and post-vaccination in the natural infection group were significantly higher than those at pre- and post-vaccination in the vaccination group (p<0.05 and p<0.05, respectively).

CONCLUSION: Pre-vaccination interferon-gamma levels in each HI antibody titer group were similar. And there were some subjects with antibody-positive exhibited CMI-negative. These data may explain why rubella reinfection can occur in vaccinated seropositive individuals.

Study Type : Human Study

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.