Abstract Title:

Effects of Shilajit on the development of tolerance to morphine in mice.

Abstract Source:

Biochem Biophys Res Commun. 2005 Jun 17;331(4):1515-21. PMID: 11268125

Abstract Author(s):

P Tiwari, P Ramarao, S Ghosal

Article Affiliation:

Faculty of Pharmacy and Medical Sciences, Post Box No. 232, Amman University, Amman 19328, Jordan. vndna@firstnet.com.jo


Effects of concomitant administration of Processed Shilajit (PS, 0.1 and 1 mg/kg, i.p.), in Swiss mice were evaluated on the development of tolerance to morphine induced analgesia in the hot plate test. Chronic administration of morphine (10 mg/kg, i.p., b.i.d.) to mice over a duration of 10 days resulted in the development of tolerance to the analgesic effect of morphine. Concomitant administration of PS with morphine, from day 6 to day 10, resulted in a significant inhibition of the development of tolerance to morphine (10 mg/kg, i.p.) induced analgesia. Processed Shilajit per se, in the doses used, did not elicit any significant analgesia in mice; nor did the chronic concomitant administration of Processed Shilajit alter the morphine-induced analgesia. These findings with Processed Shilajit indicate its potential as a prospective modifier of analgesic tolerance to morphine.

Study Type : Animal Study

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