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Abstract Title:

Antifungal effect of silver nanoparticles on dermatophytes.

Abstract Source:

J Microbiol Biotechnol. 2008 Aug;18(8):1482-4. PMID: 18756112

Abstract Author(s):

Keuk-Jun Kim, Woo Sang Sung, Seok-Ki Moon, Jong-Soo Choi, Jong Guk Kim, Dong Gun Lee

Abstract:

Spherical silver nanoparticles (nano-Ag) were synthesized and their antifungal effects on fungal pathogens of the skin were investigated. Nano-Ag showed potent activity against clinical isolates and ATCC strains of Trichophyton mentagrophytes and Candida species (IC80, 1-7 mug/ml). The activity of nano-Ag was comparable to that of amphotericin B, but superior to that of fluconazole (amphotericin B IC80, 1-5 mug/ml; fluconazole IC80, 10- 30 mug/ml). Additionally, we investigated their effects on the dimorphism of Candida albicans. The results showed nano-Ag exerted activity on the mycelia. Thus, the present study indicates nano-Ag may have considerable antifungal activity, deserving further investigation for clinical applications.

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Sayer Ji
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