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Article Publish Status: FREE
Abstract Title:

Sinensetin attenuates LPS-induced inflammation by regulating the protein level of IκB-α.

Abstract Source:

Biosci Biotechnol Biochem. 2012 ;76(4):847-9. Epub 2012 Apr 7. PMID: 22484952

Abstract Author(s):

Hye-Sun Shin, Seong-Il Kang, Seon-A Yoon, Hee-Chul Ko, Se-Jae Kim

Article Affiliation:

Hye-Sun Shin

Abstract:

Sinensetin is one of the polymethoxyflavones (PMFs) having five methoxy groups on the basic benzo-γ-pyrone skeleton with a carbonyl group at the C(4) position. We investigated in this study the anti-inflammatory activity of sinensetin in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Sinensetin showed anti-inflammatory activity by regulating the protein level of inhibitor κB-α (IκB-α).

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