Sinensetin attenuates LPS-induced inflammation by regulating the protein level of IκB-α. - GreenMedInfo Summary
Sinensetin attenuates LPS-induced inflammation by regulating the protein level of IκB-α.
Biosci Biotechnol Biochem. 2012 ;76(4):847-9. Epub 2012 Apr 7. PMID: 22484952
Hye-Sun Shin
Sinensetin is one of the polymethoxyflavones (PMFs) having five methoxy groups on the basic benzo-γ-pyrone skeleton with a carbonyl group at the C(4) position. We investigated in this study the anti-inflammatory activity of sinensetin in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Sinensetin showed anti-inflammatory activity by regulating the protein level of inhibitor κB-α (IκB-α).