[Effect of sinomenine on tumor necrosis factor-alpha and nuclear factor-kappaB in the heterotopic tissue in rats with endometriosis].
Nan Fang Yi Ke Da Xue Xue Bao. 2010 Aug;30(8):1874-6. PMID: 20813690
Basic Medical School, Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China. email@example.com
OBJECTIVE: To investigate the effect of sinomenine on the level of tumor necrosis factor-alpha (TNF-alpha) and nuclear factor-kappaB (NF-kappaB) and in the heterotopic tissue in rats with endometriosis.
METHODS: The rats with endometriosis were divided into sinomenine lavage group, blank control group, model group and dannazol group, and the levels of TNF-alpha and NF-kappaB in the heterotopic tissues of the rats were detected with immunohistochemistry.
RESULTS: Sinomenine lavage and dannazol treatment both significantly decreased the levels of levels of TNF-alpha and NF-kappaB in the heterotopic tissues of the rats as compared with the model group (P<0.05), and lesions were significantly smaller in sinomenine lavage group than in dannazol group.
CONCLUSION: Sinomenine can inhibit the production and activity of TNF-alpha and NF-kappaB to suppress the adhesion, implantation, infiltration and growth of the endometrial cells in the rat model of endometriosis.