Abstract Title:

Sintocalmy, a Passiflora incarnata Based Herbal, Attenuates Morphine Withdrawal in Mice.

Abstract Source:

Neurochem Res. 2021 May ;46(5):1092-1100. Epub 2021 Feb 5. PMID: 33544325

Abstract Author(s):

Lucas Dos Reis Izolan, Douglas Marques da Silva, Helena Beatriz Larrosa Oliveira, Janaína Lucas de Oliveira Salomon, Caroline Portela Peruzzi, Solange C Garcia, Eliane Dallegrave, Caroline Zanotto, Elaine Elisabetsky, Carlos Alberto Gonçalves, Marcelo Dutra Arbo, Eduardo Luis Konrath, Mirna Bainy Leal

Article Affiliation:

Lucas Dos Reis Izolan


Chronic opioid use changes brain chemistry in areas related to reward processes, memory, decision-making, and addiction. Both neurons and astrocytes are affected, ultimately leading to dependence. Passiflora incarnata L. (Passifloraceae) is the basis of frequently used herbals to manage anxiety and insomnia, with proven central nervous system depressant effects. Anti-addiction properties of P. incarnata have been reported. The aim of this study was to investigate the effect of a commercial extract of Passiflora incarnata (Sintocalmy®, Aché Laboratory) in the naloxone-induced jumping mice model of morphine withdrawal. In addition, glial fibrillary acidic protein (GFAP) and S100 calcium-binding protein B (S100B) levels were assessed in the frontal cortex and hippocampus, and DNA damage was verified on blood cells. In order toimprove solubilization a Sintocalmy methanol extract (SME) was used. SME is mainly composed by flavonoids isovitexin and vitexin. The effects of SME 50, 100 and 200 mg/kg (i.p.) were evaluated in the naloxone-induced withdrawal syndrome in mice. SME 50 and SME 100 mg/kg decreased naloxone-inducedjumping in morphine-dependent mice without reducing locomotor activity. No alterations were found in GFAP levels, however SME 50 mg/kg prevented the S100B increase in the frontal cortex and DNA damage. This study shows anti-addiction effects for a commercial standardized extract of P. incarnata andsuggests the relevance of proper clinical assessment.

Study Type : Animal Study

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